Year 1346 (MCCCXLVI) was a common year starting on Sunday (link will display the full calendar) of the Julian calendar. It was a year in the 14th century, in the midst of a period known in European history as the Late Middle Ages. In Asia that year, the Black Death came to the troops of the Golden Horde Khanate; the disease also affected the Genoese Europeans they were attacking, before spreading to the rest of Europe. In Central and East Asia, there was a series of revolts after Kazan Khan was killed in an uprising, and the Chagatai Khanate began to splinter and fall; several revolts in China began what would eventually lead to the overthrow of the Yuan dynasty. The Indian kingdom of Vijayanagara won several victories over Muslim conquerors in the north in this year as well.

In Eastern Europe, Stefan Dušan was proclaimed Tsar of Serbia on April 16 (Easter Sunday) at Skopje. In the nearby Byzantine Empire, the Ottoman emir Orhan married Byzantine princess Theodora as part of an alliance between her father John VI Kantakouzenos and the Ottomans. Ongoing civil wars in both Bulgaria and Byzantium continued. Denmark sold its portion of Northern Estonia to the Livonian Order of the Teutonic Knights after finally quelling the St. George's Night Uprising. In Central Europe, Charles IV of Luxembourg was elected Roman King on July 11. A number of banking families in Italy, including the Bardi family, faced bankruptcy in this year, and much of Italy suffered a famine. The Hundred Years' War between the Kingdom of France and the Kingdom of England continued in Western Europe, as Edward III of England led an invasion onto the continent and won a number of victories.